Structure of PDB 6ztb Chain I

Receptor sequence
>6ztbI (length=217) Species: 9606 (Homo sapiens) [Search protein sequence]
GPDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPE
GVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIV
TDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAY
SIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDG
DGSTTTAVAVVEILDAN
3D structure
PDB6ztb PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies.
ChainI
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA I N209 H211 D241 D243 N250 D302 N104 H106 D136 D138 N145 D197
BS02 CA I E118 D174 E176 D210 E13 D69 E71 D105
BS03 CA I E118 E176 D207 Q208 D210 D243 E13 E71 D102 Q103 D105 D138
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609 cell-cell adhesion
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ztb, PDBe:6ztb, PDBj:6ztb
PDBsum6ztb
PubMed33879555
UniProtP22223|CADH3_HUMAN Cadherin-3 (Gene Name=CDH3)

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