Structure of PDB 6zr2 Chain I

Receptor sequence

>6zr2I (length=178) Species: 10090 (Mus musculus)

TYKYVNKKEQESEVDMKSATDNAARILMWTELIRGLGMTLSYLFREPATI
NYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEP
RADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELL
YNKEKLLNNGDKWEAEIAANIQADYLYR

3D structure

• PDB: 6zr2 Structure of inhibitor-bound mammalian complex I.
• Chain: I
• Resolution: 3.1 Å

Enzymatic activity

• Enzyme Commision number: 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	I	H67 C89 C118 I119 Y120 C121 G122 C124 E135	H67 C89 C118 I119 Y120 C121 G122 C124 E135
BS02	SF4	I	C79 I80 A81 C82 K83 C85 Y111 C128	C79 I80 A81 C82 K83 C85 Y111 C128

Gene Ontology

Molecular Function

• GO:0003954 NADH dehydrogenase activity
• GO:0005515 protein binding
• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0016491 oxidoreductase activity
• GO:0016651 oxidoreductase activity, acting on NAD(P)H
• GO:0046872 metal ion binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0006120 mitochondrial electron transport, NADH to ubiquinone
• GO:0009060 aerobic respiration
• GO:0032981 mitochondrial respiratory chain complex I assembly
• GO:0042776 proton motive force-driven mitochondrial ATP synthesis
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0016020 membrane
• GO:0045271 respiratory chain complex I

External links

• PDB: RCSB:6zr2, PDBe:6zr2, PDBj:6zr2
• PDBsum: 6zr2
• PubMed: 33067417
• UniProt: Q8K3J1|NDUS8_MOUSE NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (Gene Name=Ndufs8)