Structure of PDB 6wc5 Chain I

Receptor sequence
>6wc5I (length=55) Species: 9606 (Homo sapiens) [Search protein sequence]
RVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRY
KSKRQ
3D structure
PDB6wc5 Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface.
ChainI
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 dna I Y162 R168 Q187 R190 Y191 K194 Y21 R27 Q46 R49 Y50 K53
BS02 dna I F145 Q181 W185 N188 K192 F4 Q40 W44 N47 K51
Gene Ontology
Molecular Function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function

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Biological Process
External links
PDB RCSB:6wc5, PDBe:6wc5, PDBj:6wc5
PDBsum6wc5
PubMed32681840
UniProtP52952|NKX25_HUMAN Homeobox protein Nkx-2.5 (Gene Name=NKX2-5)

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