Structure of PDB 6wc5 Chain I
Receptor sequence
>6wc5I (length=55) Species:
9606
(Homo sapiens) [
Search protein sequence
]
RVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRY
KSKRQ
3D structure
PDB
6wc5
Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface.
Chain
I
Resolution
2.9 Å
3D
structure
[
Spin on
]
[
Spin off
]
[
Reset orientation
]
[
High quality
]
[
Low quality
]
[
White background
]
[
Black background
]
[
Download
]
[
Download structure with residue number starting from 1
]
Enzymatic activity
Enzyme Commision number
?
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
dna
I
Y162 R168 Q187 R190 Y191 K194
Y21 R27 Q46 R49 Y50 K53
BS02
dna
I
F145 Q181 W185 N188 K192
F4 Q40 W44 N47 K51
Gene Ontology
Molecular Function
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677
DNA binding
Biological Process
GO:0006355
regulation of DNA-templated transcription
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:6wc5
,
PDBe:6wc5
,
PDBj:6wc5
PDBsum
6wc5
PubMed
32681840
UniProt
P52952
|NKX25_HUMAN Homeobox protein Nkx-2.5 (Gene Name=NKX2-5)
[
Back to BioLiP
]