Structure of PDB 6td5 Chain I

Receptor sequence
>6td5I (length=219) Species: 5661 (Leishmania donovani) [Search protein sequence]
TTIVGVVYRDGVVLGADTRATEGSIVADKRCRKIHYMAPNIMCCGAGTSA
DTEAVTNMVSSHLALHRLETGKQSRVLEALTLLKRHLYRYQGHVSAALVL
GGVDVEGPFLATIAPHGSTDRLPFVTMGSGSIAAMAQLEAAYKDNMTCEE
AKELVASAIRKGIFNDPYSGTQVDVCVITKDKTELTIGYDKPNERMYPRQ
EVLLPPGTTPVLKEEIRQL
3D structure
PDB6td5 Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.
ChainI
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T30 D46 R48 K62 G76 S158 D195 S198
Catalytic site (residue number reindexed from 1) T1 D17 R19 K33 G47 S129 D166 S169
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BO2 I T30 A49 T50 E51 K62 G76 T77 S78 T1 A20 T21 E22 K33 G47 T48 S49
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Cellular Component
External links
PDB RCSB:6td5, PDBe:6td5, PDBj:6td5
PDBsum6td5
PubMed32667203
UniProtA0A3Q8IVH0

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