Structure of PDB 6rwl Chain I

Receptor sequence
>6rwlI (length=270) Species: 11723 (Simian immunodeficiency virus) [Search protein sequence]
GFLDGIEKAQEEHEKYHNNWRAMAEDFQIPQVVAKEIVAQCPKCQVKGEA
MHGQVDASPKTWQMDCTHLEGKVIIVAVHVASGYIEAEVLPAETGKETAH
FLLKLAARWPVKHLHTDNGDNFTSSAVQAVCWWAQIEHTFGVPYNPQSQG
VVESMNHQLKTIITQIRDQAEKIETAVQMAVLIHNFKRKGGIGGYSAGER
IIDIIASDLQTTKLQNQISKIQNFRVYFREGRDQQWKGPATLIWKGEGAV
VIQDGQDLKVVPRRKCKIIK
3D structure
PDB6rwl Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
ChainI
Resolution3.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna I Q30 A49 Q31 A50
BS02 dna I P145 E152 K159 P146 E153 K160
BS03 dna I G52 Q53 V54 V141 Q146 S147 G149 S153 M154 G53 Q54 V55 V142 Q147 S148 G150 S154 M155
BS04 ZN I H12 H16 C40 H13 H17 C41
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:6rwl, PDBe:6rwl, PDBj:6rwl
PDBsum6rwl
PubMed32001525
UniProtE1ANT8

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