Structure of PDB 6jcz Chain I

Receptor sequence
>6jczI (length=330) Species: 273057 (Saccharolobus solfataricus P2) [Search protein sequence]
KTVLDANLDPLKGKTIGVIGYGNQGRVQATIMRENGLNVIVGNVKDKYYE
LAKKEGFEVYEIDEAVRRSDVALLLIPDEVMKEVYEKKIAPVLQGKKEFV
LDFASGYNVAFGLIRPPKSVDTIMVAPRMVGEGIMDLHKQGKGYPVLLGV
KQDASGKAWDYAKAIAKGIGAIPGGIAVISSFEEEALLDLMSEHTWVPIL
FGAIKACYDIAVKEYGVSPEAALLEFYASGELAEIARLIAEEGIFNQMVH
HSTTSQYGTLTRMFKYYDVVRRIVENEAKYIWDGSFAKEWSLEQQAGYPV
FYRLWELATQSEMAKAEKELYKLLGRKVKN
3D structure
PDB6jcz Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase.
ChainI
Resolution3.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.86: ketol-acid reductoisomerase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG I D191 E195 D189 E193
BS02 NDP I Y23 G24 N25 Q26 N45 V46 V82 Y21 G22 N23 Q24 N43 V44 V80
BS03 9TY I S107 D191 E195 S105 D189 E193
Gene Ontology
Molecular Function
GO:0004455 ketol-acid reductoisomerase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009099 L-valine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6jcz, PDBe:6jcz, PDBj:6jcz
PDBsum6jcz
PubMed30921515
UniProtQ97YJ9|ILVC2_SACS2 Putative ketol-acid reductoisomerase 2 (Gene Name=ilvC2)

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