Structure of PDB 6hec Chain I

Receptor sequence
>6hecI (length=390) Species: 224325 (Archaeoglobus fulgidus DSM 4304) [Search protein sequence]
LLEKLKKLEEDYYKLRELYRRLEDEKKFIESERIRYEREVRRLRSEVERL
RSPPLLVGVVSDILEDGRVVVKSSTGPKFVVNTSQYINEEELKPGARVAL
NQQTLAIVNVLPTSKDPMVYGFEVEEKPEVSYEDIGGLDVQIEEIREAVE
LPLLKPELFAEVGIEPPKGVLLYGPPGTGKTLLAKAVANQTRATFIRVVG
SEFVQKYIGEGARLVREVFQLAKEKAPSIIFIDELDAIAARRTNSDTSGD
REVQRTMMQLLAELDGFDPRGDVKVIGATNRIDILDPAILRPGRFDRIIE
VPLPTFEGRIQIFKIHTRKMKLAEDVDFKELARITEGASGADIKAICTEA
GMFAIREERAKVTMLDFTKAIEKVLKKTTPIPDLKGVMFV
3D structure
PDB6hec Cryo-EM structures of the archaeal PAN-proteasome reveal an around-the-ring ATPase cycle.
ChainI
Resolution6.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP I L269 R299 L261 R291
BS02 ATP I P184 G185 T186 G187 K188 T189 L190 H324 G348 A349 K352 P176 G177 T178 G179 K180 T181 L182 H316 G340 A341 K344
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0010498 proteasomal protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043335 protein unfolding
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005737 cytoplasm
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0022623 proteasome-activating nucleotidase complex

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Cellular Component
External links
PDB RCSB:6hec, PDBe:6hec, PDBj:6hec
PDBsum6hec
PubMed30559193
UniProtO28303|PAN_ARCFU Proteasome-activating nucleotidase (Gene Name=pan)

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