Structure of PDB 6gmq Chain I

Receptor sequence
>6gmqI (length=144) Species: 9606 (Homo sapiens) [Search protein sequence]
VLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHS
YRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKER
CLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQER
3D structure
PDB6gmq Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
ChainI
Resolution2.755 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F4K I L118 R120 G127 L128 L129 E134 L201 L57 R59 G66 L67 L68 E73 L140 PDBbind-CN: -logKd/Ki=2.30,Kd=5.0mM
External links
PDB RCSB:6gmq, PDBe:6gmq, PDBj:6gmq
PDBsum6gmq
PubMed30040896
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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