Structure of PDB 6esq Chain I

Receptor sequence
>6esqI (length=347) Species: 2186 (Methanothermococcus thermolithotrophicus) [Search protein sequence]
KDIGIVGYGSYIPKYRIKVEEIAKVWGKDPEAIKKGLVVNEKSVPSPDED
TATIAVEAARNAVKRAGINAEKIGAVYVGSESHPYAVKPTSATVAEAIGA
TPDLTAADLEFACKAGTAGIQMCMGLVGSGLIEYGMAIGADTAQGAPGDA
LEYTASAGGAAYIIGNKKDEMIAVFNGTYSYTTDTPDFWRREGQSYPKHG
GRFTGEPAYFKHVLNAAKGIMEKMGTTVKDYDYCVFHQPNGKFYIKAAKS
LGFTNEQYKYGLLTPYLGNTYSGAVPLGLSNILDHAEEGARILAVSYGSG
AGSDAFDITVTERIKEVVDKAPKTLDLLNRKKYIDYAVYVKYRGKIK
3D structure
PDB6esq Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site.
ChainI
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.10: hydroxymethylglutaryl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA I R203 K243 R202 K242
Gene Ontology
Molecular Function
GO:0004421 hydroxymethylglutaryl-CoA synthase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006084 acetyl-CoA metabolic process
GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:6esq, PDBe:6esq, PDBj:6esq
PDBsum6esq
PubMed29531083
UniProtA0A384E143

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