Structure of PDB 5us1 Chain I

Receptor sequence
>5us1I (length=178) Species: 588 (Providencia stuartii) [Search protein sequence]
MGIEYRSLHTSQLTLSEKEALYDLLIEGFEGDFSHDDFAHTLGGMHVMAF
DQQKLVGHVAIIQRHMALDNTPISVGYVEAMVVEQSYRRQGIGRQLMLQT
NKIIASCYQLGLLSASDDGQKLYHSVGWQIWKGKLFELKQGSYIRSIEEE
GGVMGWKADGEVDFTASLYCDFRGGDQW
3D structure
PDB5us1 Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.
ChainI
Resolution2.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.59: gentamicin 2'-N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8MM I D37 M81 S114 S116 E149 W178 D37 M81 S114 S116 E149 W178
BS02 COA I F29 M81 V82 V83 R88 R89 G91 G93 R94 S116 K121 Y123 F29 M81 V82 V83 R88 R89 G91 G93 R94 S116 K121 Y123
Gene Ontology
Molecular Function
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0047921 aminoglycoside 2'-N-acetyltransferase activity
Biological Process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:5us1, PDBe:5us1, PDBj:5us1
PDBsum5us1
PubMed29634241
UniProtQ52424|AAC2_PROST Aminoglycoside 2'-N-acetyltransferase (Gene Name=aac)

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