Structure of PDB 5o5k Chain I

Receptor sequence
>5o5kI (length=216) Species: 1299331 (Mycobacterium intracellulare 1956) [Search protein sequence]
AVMEAEYERSEALLANMLPGSIAERLKSSSRSVIADKYDEVSVLFADIVG
FTERASTTTPADLVRFLNRLYGAFDELVDKHGLEKIKVSGDSYMVVSGVP
RARPDHAFALADFALDMANVAAALKDPHGDPVPLRMGMACGPVVAGVVGS
RRFFYDVWGDAVNVASRMESTDSVGRIQVPEAMYERLKNEFVLQERGRIE
VKGKGVMRTWYLIGRK
3D structure
PDB5o5k Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation.
ChainI
Resolution3.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D256 I257 D300 R376 K411
Catalytic site (residue number reindexed from 1) D47 I48 D91 R167 K202
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN I D256 I257 D300 D47 I48 D91
BS02 MN I D256 D300 D47 D91
BS03 ONM I I257 V258 F260 T261 P269 L272 S298 G299 D300 R344 I48 V49 F51 T52 P60 L63 S89 G90 D91 R135
BS04 ONM I F254 K296 M303 W367 G368 D369 V371 N372 S375 F45 K87 M94 W158 G159 D160 V162 N163 S166
Gene Ontology
Molecular Function
GO:0016849 phosphorus-oxygen lyase activity
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:5o5k, PDBe:5o5k, PDBj:5o5k
PDBsum5o5k
PubMed29087332
UniProtX8CHM4

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