Structure of PDB 5mnv Chain I

Receptor sequence
>5mnvI (length=286) Species: 1890 (Streptomyces antibioticus) [Search protein sequence]
HYAELRRDEPVSRVTRMSDARIVLGRMFPTPVLAQDPPDHTRLRRLVGKA
FTARRVEEMRPRVRSLVDSLLDDMVAHGSPADLVEFLAVPFPVAVICELL
GVPLEDRDLFRTFSDAMLSAEIQRVQQDFMVYMDGLVAQRRDAPTEDLLG
ALALATDNDTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTERKRYESL
VADPAAVEEMLRYTPLVSDEEVFDHADELDGAHHCIGAQLGRLELQEALS
ALVRRFPTLDLAEPVAGLKWKQGMLIRGLERQIVSW
3D structure
PDB5mnv Substrate-induced conformational change in cytochrome P450 OleP.
ChainI
Resolution2.97 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S180 A244 E247 T248 S249 S292 C356 I357 G358 E365 I397
Catalytic site (residue number reindexed from 1) S119 A174 E177 T178 S179 S218 C235 I236 G237 E244 I276
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM I V93 L94 A244 G245 T248 H354 C356 I357 L361 V32 L33 A174 G175 T178 H233 C235 I236 L240
BS02 DEB I F84 L94 S240 A244 L396 F28 L33 S170 A174 L275
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5mnv, PDBe:5mnv, PDBj:5mnv
PDBsum5mnv
PubMed30207799
UniProtQ59819

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