Structure of PDB 5iyc Chain I

Receptor sequence

>5iycI (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]

MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADN
SCIYVNKITHEVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSH
SARAEDAMRLYYVCTAPHCGHRWTE

3D structure

PDB

5iyc Near-atomic resolution visualization of human transcription promoter opening.

Chain

Resolution

3.9 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	I	C17 C39	C17 C39
BS02	ZN	I	C86 C89 C114 C119	C86 C89 C114 C119

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003899	DNA-directed 5'-3' RNA polymerase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

	Biological Process
GO:0001193	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006351	DNA-templated transcription
GO:0006366	transcription by RNA polymerase II
GO:0006367	transcription initiation at RNA polymerase II promoter

	Cellular Component
GO:0000428	DNA-directed RNA polymerase complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005665	RNA polymerase II, core complex
GO:0005730	nucleolus

External links

PDB	RCSB:5iyc, PDBe:5iyc, PDBj:5iyc
PDBsum	5iyc
PubMed	27193682
UniProt	P36954\|RPB9_HUMAN DNA-directed RNA polymerase II subunit RPB9 (Gene Name=POLR2I)