Structure of PDB 5gjq Chain I

Receptor sequence
>5gjqI (length=359) Species: 9606 (Homo sapiens) [Search protein sequence]
LERIKDYLLMEEEFIRNQEQKQEEERSKVDDLRGTPMSVGTLEEIIDDNH
AIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPL
VTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPK
GVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVREL
FRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFD
SRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTS
RMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFK
KSKENVLYK
3D structure
PDB5gjq An atomic structure of the human 26S proteasome.
ChainI
Resolution4.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP I R343 R346 R273 R276
BS02 ADP I G188 G229 T230 G231 T233 L234 I364 H368 G392 K396 G118 G159 T160 G161 T163 L164 I294 H298 G322 K326
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005838 proteasome regulatory particle
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5gjq, PDBe:5gjq, PDBj:5gjq
PDBsum5gjq
PubMed27428775
UniProtP62191|PRS4_HUMAN 26S proteasome regulatory subunit 4 (Gene Name=PSMC1)

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