Structure of PDB 5fur Chain I

Receptor sequence

>5furI (length=912) Species: 9606 (Homo sapiens)

KLTHQVVCINNINFQRKSVVGFVELTIFPTVANLNRIKLNSKQCRIYRVR
INDLEAAFIYNELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVV
PSVEGSMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMV
AVSNGDLVETVYTHDMRKKTFHYMLTIPTAASNISLAIGPFEILVDPYMH
EVTHFCLPQLLPLLKHTTSYLHEVFEFYEEILTCRYPYSCFKTVFIDEAY
VEVAAYASMSIFSTNLLHSAMIIDETPLTRRCLAQSLAQQFFGCFISRMS
WSDEWVLKGISGYIYGLWMKKTFGVNEYRHWIKEELDKIVAYELKTGGVL
LHPIFGGGKEKDNPASHLHFSIKHPHTLSWEYYSMFQCKAHLVMRLIENR
ISMEFMLQVFNKLLSLASTASSQKFQSHMWSQMLVSTSGFLKSISNVSGK
DIQPLIKQWVDQSGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGP
LKVTVQELDGSFNHTLQIEENSLKHDIPCHSKSRRNKKKKIPLMNGEEVD
MDLSAMDADSPLLWIRIDPDMSVLRKVEFEQADFMWQYQLRYERDVVAQQ
ESILALEKFPTPASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTW
TGPPAMKSLFTRMFCCKSCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDV
HNLCPKEVLTFILDLIKYNDNRKNKFSDNYYRAEMIDALANSVTPAVSVN
NEVRTLDNLNPDVRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRVLQK
NGHVPSDPALFKSYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNM
IQNDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTSH
DWRLRCGAVDLY

3D structure

• PDB: 5fur Structure of Promoter-Bound TFIID and Model of Human Pre-Initiation Complex Assembly.
• Chain: I
• Resolution: 8.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	I	N542 C592	N479 C529
BS02	peptide	I	K730 P733 N782 D783 N784 R827 L828 E831 L837 N838	K667 P670 N719 D720 N721 R764 L765 E768 L774 N775

Gene Ontology

Molecular Function

• GO:0000976 transcription cis-regulatory region binding
• GO:0003682 chromatin binding
• GO:0005515 protein binding
• GO:0016251 RNA polymerase II general transcription initiation factor activity

Biological Process

• GO:0000086 G2/M transition of mitotic cell cycle
• GO:0006282 regulation of DNA repair
• GO:0006357 regulation of transcription by RNA polymerase II
• GO:0006367 transcription initiation at RNA polymerase II promoter
• GO:0014070 response to organic cyclic compound
• GO:0042789 mRNA transcription by RNA polymerase II
• GO:0045893 positive regulation of DNA-templated transcription
• GO:0051123 RNA polymerase II preinitiation complex assembly
• GO:0060261 positive regulation of transcription initiation by RNA polymerase II

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005669 transcription factor TFIID complex
• GO:0033276 transcription factor TFTC complex

External links

• PDB: RCSB:5fur, PDBe:5fur, PDBj:5fur
• PDBsum: 5fur
• PubMed: 27007846
• UniProt: Q6P1X5|TAF2_HUMAN Transcription initiation factor TFIID subunit 2 (Gene Name=TAF2)