Structure of PDB 5flv Chain I

Receptor sequence
>5flvI (length=226) Species: 10090 (Mus musculus) [Search protein sequence]
PRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRR
YKSKRQRVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVVTGLNPKTK
YILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWM
RQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADSTHVFPETAF
IAVTSYQNHKITQLKIENNPFAKGFR
3D structure
PDB5flv Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.
ChainI
Resolution3.005 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna I F144 Q180 I183 W184 N187 K191 N1162 S1175 T1215 P1231 F1232 K1234 G1235 F5 Q41 I44 W45 N48 K52 N163 S176 T204 P220 F221 K223 G224 PDBbind-CN: Kd~50nM
BS02 dna I R141 Y161 Q186 R189 Y190 R1081 R1082 K1159 Y1217 T1223 N1230 F1232 F1236 R2 Y22 Q47 R50 Y51 R83 R84 K160 Y206 T212 N219 F221 F225 PDBbind-CN: Kd~50nM
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5flv, PDBe:5flv, PDBj:5flv
PDBsum5flv
PubMed26875865
UniProtP42582;
P70326

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