Structure of PDB 5epi Chain I

Receptor sequence

>5epiI (length=708) Species: 1601067 (Influenza B virus (B/Memphis/13/2003))

SMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVIS
DMNFLDEEGKARPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKYLADLFD
YKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLSNESSL
DEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDIDFKLGQTISRLRDISV
PAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKLTWEDLRPIG
PHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLAKECLEKYSTL
RDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNELQKTNYAKWAT
GDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTEMNLLSTLTSK
RALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMKYVLFHTSLL
NESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHLRGDTDVVTV
VTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLYCRVNGTNKIQ
MKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKGDRVNSPKTFS
IGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAESRRLLLLIQ
ALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNEWLGFEKEGSKV
LESVDEIM

3D structure

• PDB: 5epi Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.
• Chain: I
• Resolution: 4.1 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	I	T366 G367 G369 L370 T371 Y372 H506 V513 T515 R558 V559 N560 G561 T562	T350 G351 G353 L354 T355 Y356 H490 V497 T499 R542 V543 N544 G545 T546

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:5epi, PDBe:5epi, PDBj:5epi
• PDBsum: 5epi
• PubMed: 26711008
• UniProt: Q5V8Z9