Structure of PDB 4yig Chain I

Receptor sequence
>4yigI (length=220) Species: 10249 (Vaccinia virus Copenhagen) [Search protein sequence]
DPMNSVTVSHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDK
FFIQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISR
LTGVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHI
TKHVSVLYCLGKTDFSNIRAKLESPVTTIVGYHPAARDRQFEKDRSFEII
NVLLELDNKVPINWAQGFIY
3D structure
PDB4yig Crystal Structure of the Vaccinia Virus Uracil-DNA Glycosylase in Complex with DNA.
ChainI
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna I D68 P69 Y70 P71 K72 K87 S88 T130 G159 K160 T161 Y180 H181 A183 R185 D70 P71 Y72 P73 K74 K89 S90 T132 G161 K162 T163 Y182 H183 A185 R187
BS02 dna I R185 R187 R187 R189
BS03 URA I G66 D68 Y70 P78 F79 N120 H181 G68 D70 Y72 P80 F81 N122 H183
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004844 uracil DNA N-glycosylase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0006281 DNA repair
GO:0039693 viral DNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4yig, PDBe:4yig, PDBj:4yig
PDBsum4yig
PubMed26045555
UniProtP20536|UNG_VACCC Uracil-DNA glycosylase (Gene Name=OPG116)

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