Structure of PDB 4w9i Chain I

Receptor sequence
>4w9iI (length=143) Species: 9606 (Homo sapiens) [Search protein sequence]
VLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHS
YRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKER
CLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQE
3D structure
PDB4w9i Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
ChainI
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3JS I F76 W88 Y98 R107 I109 H110 S111 Y112 H115 W117 F15 W27 Y37 R46 I48 H49 S50 Y51 H54 W56 MOAD: Kd=1.1uM
BindingDB: Kd=1100nM
External links
PDB RCSB:4w9i, PDBe:4w9i, PDBj:4w9i
PDBsum4w9i
PubMed25166285
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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