Structure of PDB 4ogr Chain I

Receptor sequence
>4ogrI (length=319) Species: 9606 (Homo sapiens) [Search protein sequence]
VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKE
GFPITALREIKILQLLKHENVVNLIEICRTKASPKGSIYLVFDFCEHDLA
GLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG
VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPID
LWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYEL
YEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN
HDFFWSDPMPSDLKGMLST
3D structure
PDB4ogr AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter.
ChainI
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N154 D167 S180 T191
Catalytic site (residue number reindexed from 1) N143 D156 S169 T180
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADN I I25 F105 C106 D109 A153 L156 I18 F94 C95 D98 A142 L145
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4ogr, PDBe:4ogr, PDBj:4ogr
PDBsum4ogr
PubMed24843025
UniProtP50750|CDK9_HUMAN Cyclin-dependent kinase 9 (Gene Name=CDK9)

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