Structure of PDB 4nqa Chain I

Receptor sequence

>4nqaI (length=385) Species: 9606 (Homo sapiens)

KGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYA
CRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQ
QQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQ
ELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTEL
AIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHET
ECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLI
AINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMK
LVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDV

3D structure

• PDB: 4nqa Structure of the retinoid X receptor alpha-liver X receptor beta (RXR alpha-LXR beta ) heterodimer on DNA.
• Chain: I
• Resolution: 3.102 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	I	V283 K287 I301 L304 P451 L452 E455	V209 K213 I227 L230 P377 L378 E381
BS02	dna	I	P77 P79 F97 H98 Y99 R112 V159 L160	P3 P5 F23 H24 Y25 R38 V85 L86
BS03	dna	I	G76 E105 G106 R113 R121 R138 R145 R171	G2 E31 G32 R39 R47 R64 R71 R97
BS04	965	I	F271 L274 S278 I309 M312 L313 T316 R319 I327 F329 L330 F340 L345 F349 I350 I353 F354 H435 W457	F197 L200 S204 I235 M238 L239 T242 R245 I253 F255 L256 F266 L271 F275 I276 I279 F280 H361 W383	BindingDB: EC50=40.0nM,IC50=23nM,Ki=2.2nM
BS05	ZN	I	C131 C141 C144	C57 C67 C70

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0004879 nuclear receptor activity
• GO:0008270 zinc ion binding
• GO:0043565 sequence-specific DNA binding

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006629 lipid metabolic process

External links

• PDB: RCSB:4nqa, PDBe:4nqa, PDBj:4nqa
• PDBsum: 4nqa
• PubMed: 24561505
• UniProt: P55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)