Structure of PDB 4f86 Chain I

Receptor sequence
>4f86I (length=273) Species: 324833 (Streptomyces lasalocidi) [Search protein sequence]
PYQEDIARYWNNEARPVNLRLGDVDGLYHHHYGIGAVDHAALGDPGDGGY
EARLIAELHRLESAQAEFLLDHLGPVGPGDTLVDAGCGRGGSMVMAHQRF
GCKVEGVTLSAAQAEFGNRRARELGIDDHVRSRVCNMLDTPFEKGTVAAS
WNNESSMYVDLHDVFAEHSRFLRVGGRYVTVTGCWNPRYGQPSKWVSQIN
AHFECNIHSRREYLRAMADNRLVPQTVVDLTPETLPYWELRATSSLVTGI
EEAFIESYRDGSFQYVLIAADRV
3D structure
PDB4f86 Structure analysis of geranyl pyrophosphate methyltransferase and the proposed reaction mechanism of SAM-dependent C-methylation
ChainI
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.255: geranyl diphosphate 2-C-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG I Q30 W37 H57 G113 C114 G115 T135 L136 Q140 N163 M164 N180 E181 S182 Y185 Q3 W10 H30 G86 C87 G88 T108 L109 Q113 N136 M137 N153 E154 S155 Y158
BS02 GPP I W37 R42 N45 H57 Y59 M184 F230 R268 F281 W10 R15 N18 H30 Y32 M157 F203 R241 F254
BS03 MG I H58 E89 H31 E62
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008168 methyltransferase activity
GO:0008169 C-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:1904047 S-adenosyl-L-methionine binding
Biological Process
GO:0032259 methylation
GO:0042214 terpene metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4f86, PDBe:4f86, PDBj:4f86
PDBsum4f86
PubMed23090405
UniProtD3KYU3|GPPMT_STRLS Geranyl diphosphate 2-C-methyltransferase (Gene Name=gdpmt)

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