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Structure of PDB 3klf Chain I

Receptor sequence

>3klfI (length=553) Species: 11678 (Human immunodeficiency virus type 1 BH10) [Search protein sequence]

ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIG
PENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLK
KKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQ
GWKGSPAIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTK
IEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDS
WTVNDICKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAEL
ELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKT
GKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETW
WTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETK
LGKAGYVTNKGRQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTDSQY
ALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKL
VSA

3D structure

PDB

3klf Structural basis of HIV-1 resistance to AZT by excision.

Chain

Resolution

3.15 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	I	W24 P25 L74 D76 R78 E89 I94 G152 P157 R284 G285 K353 R356 K374 R448 E449 N474	W23 P24 L73 D75 R77 E88 I93 G151 P156 R283 G284 K352 R355 K373 R447 E448 N473
BS02	dna	I	Y183 M184 M230 G231 N255 C258 K259 G262 K263 W266 L289 G359 A360 H361 Q475 Y501	Y182 M183 M229 G230 N254 C257 K258 G261 K262 W265 L288 G358 A359 H360 Q474 Y500
BS03	MG	I	D110 V111 D185	D109 V110 D184
BS04	MG	I	D443 D498	D442 D497
BS05	ZP4	I	K65 R72 D110 D113 A114 Y115 F116 Q151 D185 H221 L228	K64 R71 D109 D112 A113 Y114 F115 Q150 D184 H220 L227

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003964	RNA-directed DNA polymerase activity
GO:0004523	RNA-DNA hybrid ribonuclease activity

	Biological Process
GO:0006278	RNA-templated DNA biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3klf, PDBe:3klf, PDBj:3klf
PDBsum	3klf
PubMed	20852643
UniProt	P03366\|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)

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