Structure of PDB 2clp Chain I

Receptor sequence
>2clpI (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
PATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILG
GLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDL
FYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKS
NGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKY
KYEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGAS
APSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGPLEP
AVVDAFNQAWHLVAHECPNYFR
3D structure
PDB2clp Crystal Structure of Human Aflatoxin B1 Aldehyde Reductase Member 3
ChainI
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D73 Y78 P109 H142
Catalytic site (residue number reindexed from 1) D35 Y40 P71 H104
Enzyme Commision number 1.-.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP I G44 M46 D73 Y78 H142 N173 F226 N227 P228 L229 G231 G232 T235 K237 G250 R251 I315 G317 M318 S319 Q323 G6 M8 D35 Y40 H104 N135 F188 N189 P190 L191 G193 G194 T197 K199 G212 R213 I277 G279 M280 S281 Q285
Gene Ontology
Molecular Function
GO:0004033 aldo-keto reductase (NADPH) activity
GO:0005515 protein binding
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
Biological Process
GO:0006081 cellular aldehyde metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2clp, PDBe:2clp, PDBj:2clp
PDBsum2clp
PubMed
UniProtO95154|ARK73_HUMAN Aflatoxin B1 aldehyde reductase member 3 (Gene Name=AKR7A3)

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