Structure of PDB 1twf Chain I

Receptor sequence

>1twfI (length=122) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

MTTFRFCRDCNNMLYPREDKENNRLLFECRTCSYVEEAGSPLVYRHELIT
NIGETAGVVQDIGSDPTLPRSDRECPKCHSRENVFFQSQQRRKDTSMVLF
FVCLSCSHIFTSDQKNKRTQFS

3D structure

PDB

1twf Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.

Chain

Resolution

2.3 Å

3D
structure

Enzymatic activity

Enzyme Commision number

2.7.7.6: DNA-directed RNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	I	C29 C32	C29 C32
BS02	ZN	I	C75 C103	C75 C103

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003899	DNA-directed 5'-3' RNA polymerase activity
GO:0003968	RNA-dependent RNA polymerase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

	Biological Process
GO:0001172	RNA-templated transcription
GO:0001193	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006351	DNA-templated transcription
GO:0006366	transcription by RNA polymerase II
GO:0006367	transcription initiation at RNA polymerase II promoter
GO:0006368	transcription elongation by RNA polymerase II

	Cellular Component
GO:0000428	DNA-directed RNA polymerase complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005665	RNA polymerase II, core complex
GO:0005730	nucleolus
GO:0055029	nuclear DNA-directed RNA polymerase complex

External links

PDB	RCSB:1twf, PDBe:1twf, PDBj:1twf
PDBsum	1twf
PubMed	15537538
UniProt	P27999\|RPB9_YEAST DNA-directed RNA polymerase II subunit RPB9 (Gene Name=RPB9)