Structure of PDB 1soj Chain I

Receptor sequence
>1sojI (length=364) Species: 9606 (Homo sapiens) [Search protein sequence]
LDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTG
LLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVP
GLQQIHNGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYD
HPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHL
DHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNEND
RLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPIS
PFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAESRRRIFC
QLMHHLTENHKIWK
3D structure
PDB1soj Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity
ChainI
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG I H741 H821 D822 D937 H83 H147 D148 D263
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1soj, PDBe:1soj, PDBj:1soj
PDBsum1soj
PubMed15147193
UniProtQ13370|PDE3B_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Gene Name=PDE3B)

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