Structure of PDB 1s4e Chain I

Receptor sequence
>1s4eI (length=351) Species: 2261 (Pyrococcus furiosus) [Search protein sequence]
SKITVKSPGRVNLIGEHTDYTYGYVMPMAIDLYTIITAEKYDKVQLYSEH
FNEEKTFTLDNLTKEGSWIDYVKGVLWVLIQEGYKIGGLKGKITGDLPLG
AGLSSSASFEVGILEVLNQLYNLNIDPLKKALLAKKAENEFVGVPCGILD
QFAVVFGKKDNVIFLDTQTLQYEYIPFPKDVSVLVFYTGVKRELASSEYA
ERKRIAEESLRILGKESSKEVTEKDLGKLPPLHRKFFSYIVRENARVLEV
RDALKEGDIEKVGKILTTAHWDLAENYRVSCEELDFFVKKAMELGAYGAR
LTGAGFGGSAIALVDKDKAKTIGDAILREYLAKFSWKAKYFVVKPSDGVG
V
3D structure
PDB1s4e Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase
ChainI
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.6: galactokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLA I E17 H18 D20 G148 D151 Y200 E16 H17 D19 G147 D150 Y199
BS02 ADP I S49 F52 W69 Y72 I94 L100 G101 S105 S106 S107 F110 S48 F51 W68 Y71 I93 L99 G100 S104 S105 S106 F109
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004335 galactokinase activity
GO:0005524 ATP binding
GO:0005534 galactose binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0046872 metal ion binding
Biological Process
GO:0006012 galactose metabolic process
GO:0016310 phosphorylation
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1s4e, PDBe:1s4e, PDBj:1s4e
PDBsum1s4e
PubMed15003454
UniProtQ9HHB6|GAL1_PYRFU Galactokinase (Gene Name=galK)

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