Structure of PDB 1qdu Chain I

Receptor sequence
>1qduI (length=153) Species: 9606 (Homo sapiens) [Search protein sequence]
LDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALT
TTFEELHFEIKPHHDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKG
IIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPV
ETD
3D structure
PDB1qdu The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis.
ChainI
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R177 D178 G238 C285
Catalytic site (residue number reindexed from 1) R37 D38 G97 C139
Enzyme Commision number 3.4.22.61: caspase-8.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide I R179 H237 Q283 C285 R39 H96 Q137 C139
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1qdu, PDBe:1qdu, PDBj:1qdu
PDBsum1qdu
PubMed10508784
UniProtQ14790|CASP8_HUMAN Caspase-8 (Gene Name=CASP8)

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