Structure of PDB 1jvq Chain I

Receptor sequence

>1jvqI (length=410) Species: 9606 (Homo sapiens) [Search protein sequence]

VDICTAKPRDIPMNPMCIYRSPEEATNRRVWELSKANSRFATTFYQHLAD
SKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQ
IHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGA
KLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNT
IYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQ
VLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVV
HMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAF
HKAFLEVNEEGSASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTII
FMGRVANPCV

3D structure

PDB

1jvq How small peptides block and reverse serpin polymerisation

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	I	S82 I83 V190 R197 I198 V216 N217 T218 I219 Y220 F221 K222 G223 W225 F274 F368 H369 K370 A371 F372 L373 E374 V375 N376 F422	S64 I65 V172 R179 I180 V198 N199 T200 I201 Y202 F203 K204 G205 W207 F256 F350 H351 K352 A353 F354 L355 E356 V357 N358 F401
BS02	peptide	I	F87 T90 V201 I202 A206 V212 L213 V214 L215 L351 V364 S365 D366 A367 F368	F69 T72 V183 I184 A188 V194 L195 V196 L197 L333 V346 S347 D348 A349 F350

Gene Ontology

	Molecular Function
GO:0002020	protease binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0042802	identical protein binding

	Biological Process
GO:0007596	blood coagulation
GO:0010466	negative regulation of peptidase activity
GO:0030193	regulation of blood coagulation

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005886	plasma membrane
GO:0062023	collagen-containing extracellular matrix
GO:0070062	extracellular exosome
GO:0072562	blood microparticle

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1jvq, PDBe:1jvq, PDBj:1jvq
PDBsum	1jvq
PubMed	15342247
UniProt	P01008\|ANT3_HUMAN Antithrombin-III (Gene Name=SERPINC1)

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