Structure of PDB 1ejl Chain I

Receptor sequence

>1ejlI (length=426) Species: 10090 (Mus musculus) [Search protein sequence]

GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS

3D structure

PDB

1ejl Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	I	G281 N283 I286 V321 T322 G323 T328 K353 W357 N361 A364 E396 W399 G407	G210 N212 I215 V250 T251 G252 T257 K282 W286 N290 A293 E325 W328 G336
BS02	peptide	I	S105 R106 P110 W142 N146 S149 G150 T155 Q181 W184 N188 D192 W231 R238	S34 R35 P39 W71 N75 S78 G79 T84 Q110 W113 N117 D121 W160 R167

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1ejl, PDBe:1ejl, PDBj:1ejl
PDBsum	1ejl
PubMed	10764582
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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