Structure of PDB 8ccs Chain HH

Receptor sequence

>8ccsHH (length=296) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

AFQKDAKSSAYSSRFQTPFRRRREGKTDYYQRKRLVTQHKAKYNTPKYRL
VVRFTNKDIICQIISSTITGDVVLAAAYSHELPRYGITHGLTNWAAAYAT
GLLIARRTLQKLGLDETYKGVEEVEGEYELTEAVEDGPRPFKVFLDIGLQ
RTTTGARVFGALKGASDGGLYVPHSENRFPGWDFETEEIDPELLRSYIFG
GHVSQYMEELADDDEERFSELFKGYLADDIDADSLEDIYTSAHEAIRADP
AFKPTEKKFTKEQYAAESKKYRQTKLSKEERAARVAAKIAALAGQQ

3D structure

PDB

8ccs Cryo-EM analysis of eukaryotic ribosome translocation intermediates

Chain

Resolution

1.97 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	HH	K5 K8 A11 Y12 R15 F16 Q17 P19 R23 G26 T28 D29 Y31 R35 L36 K43 Y44 T46 K48 L113 P139 R140 P141 F142 F145 I148 L150 R152 T153 F160 P174 H175 S176 N178 R179	K4 K7 A10 Y11 R14 F15 Q16 P18 R22 G25 T27 D28 Y30 R34 L35 K42 Y43 T45 K47 L112 P138 R139 P140 F141 F144 I147 L149 R151 T152 F159 P173 H174 S175 N177 R178
BS02	rna	HH	A7 K8 S10 S13 S14 F16 T18 F20 R21 R22 R24 K27 T28 Y30 R33 R50 V52 R54 T56 N57 K58 I61 Q63 I65 I69 T70 G71 D72 V73 V74 Y79 H90 G91 N94 W95 Q151 R152 T154 T155 G156 A157 R158 Y198 H203 V204 Y207 R218 E221 L222 F253 T256 K258 K259 Y265 A266 E268 S269 K270 Y272 Q274 K276 L277 K279 R282 R285 V286 K289	A6 K7 S9 S12 S13 F15 T17 F19 R20 R21 R23 K26 T27 Y29 R32 R49 V51 R53 T55 N56 K57 I60 Q62 I64 I68 T69 G70 D71 V72 V73 Y78 H89 G90 N93 W94 Q150 R151 T153 T154 G155 A156 R157 Y197 H202 V203 Y206 R217 E220 L221 F252 T255 K257 K258 Y264 A265 E267 S268 K269 Y271 Q273 K275 L276 K278 R281 R284 V285 K288

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8ccs, PDBe:8ccs, PDBj:8ccs
PDBsum	8ccs
PubMed	38030725
UniProt	P26321\|RL5_YEAST Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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