Structure of PDB 8gxs Chain HG

Receptor sequence
>8gxsHG (length=347) Species: 9606 (Homo sapiens) [Search protein sequence]
RTKRWEGGYERTWEILKEVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCT
LKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKA
VDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYD
LIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTH
HVSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAEPGLTLGGYF
CPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYN
GERFCYGCQGELKDQHVYVCAVCQNVFCVDCDVFVHDSLHCCPGCIH
3D structure
PDB8gxs Structures of +1 nucleosome-bound PIC-Mediator complex.
ChainHG
Resolution4.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN HG C345 C348 C368 C371 C305 C308 C328 C331
BS02 ZN HG C360 C363 C382 C385 C320 C323 C342 C345
BS03 ZN HG C294 C305 C308 C254 C265 C268
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0046872 metal ion binding
Biological Process
GO:0002031 G protein-coupled receptor internalization
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006351 DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0009411 response to UV
Cellular Component
GO:0000438 core TFIIH complex portion of holo TFIIH complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005675 transcription factor TFIIH holo complex
GO:0016607 nuclear speck

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gxs, PDBe:8gxs, PDBj:8gxs
PDBsum8gxs
PubMed36201575
UniProtQ13888|TF2H2_HUMAN General transcription factor IIH subunit 2 (Gene Name=GTF2H2)

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