Structure of PDB 8gxs Chain HE

Receptor sequence
>8gxsHE (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
LNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSNKL
AVIASHIQESRFLYPGSKDGKYELLTSANEVIVEEIKDLMTKSDIKGQHT
ETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMN
VIFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLW
VFLPDQDQRSQLILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFS
PICTTCETAFKIS
3D structure
PDB8gxs Structures of +1 nucleosome-bound PIC-Mediator complex.
ChainHE
Resolution4.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN HE C268 C271 C285 C239 C242 C256
BS02 ZN HE C257 H258 C276 C228 H229 C247
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006355 regulation of DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000438 core TFIIH complex portion of holo TFIIH complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005675 transcription factor TFIIH holo complex
GO:0097550 transcription preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gxs, PDBe:8gxs, PDBj:8gxs
PDBsum8gxs
PubMed36201575
UniProtQ13889|TF2H3_HUMAN General transcription factor IIH subunit 3 (Gene Name=GTF2H3)

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