Structure of PDB 9boq Chain H

Receptor sequence

>9boqH (length=736) Species: 9606 (Homo sapiens) [Search protein sequence]

RPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIV
LSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDD
TVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPS
PYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVE
LPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLING
PEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVE
RRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGI
PDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQ
AIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEV
PQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPG
CGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAP
CVLFFDELDSIAKARGGGGAADRVINQILTEMDGMSTKKNVFIIGATNRP
DIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLA
KMTNGFSGADLTEICQRACKLAIRESIESEIRRERERPVPEIRRDHFEEA
MRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS

3D structure

PDB

9boq Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors.

Chain

Resolution

3.33 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ADP	H	I206 G248 T249 G250 T252 L253 I380 H384 G408 A409	I185 G227 T228 G229 T231 L232 I359 H363 G387 A388
BS02	ADP	H	G480 G521 C522 G523 K524 T525 L526 I656 N660 G684	G459 G500 C501 G502 K503 T504 L505 I630 N634 G658
BS03	XKM	H	P496 V497 P500 L504 M508 P510 S511 C535 K615 N616 F618	P475 V476 P479 L483 M487 P489 S490 C514 K589 N590 F592

External links

PDB	RCSB:9boq, PDBe:9boq, PDBj:9boq
PDBsum	9boq
PubMed	39122922
UniProt	P55072\|TERA_HUMAN Transitional endoplasmic reticulum ATPase (Gene Name=VCP)

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