Structure of PDB 8z99 Chain H

Receptor sequence

>8z99H (length=582) Species: 256318 (metagenome) [Search protein sequence]

MIKFIGGASKVTGSAFLLETGNAKILIDCGIEQEKGIEKDNNEIIEKKIN
EIGKADICILTHAHLAASGLVPLLVKKRKVNKIISTPATKELCRLLFNDF
QRIQEENNDIPLYSYDDIESSFEIWDEIDDRNTIELFDTKITFYNNSHII
GSVSVFIETHNGNYLFSGDIGSKLQQLMDYPPDMPDGNVDYLILESTYSH
DSSDRDRLLEIAKTTCENGGKVLIPSFAIGRLQEVLYTFSNYNFNFPVYI
DSPMGSKVTNLIKEYNIYLKKKLRRLSITDDLFNNKYIAINTSNQSKELS
NSKEPAVIISASGMLEGGRILNHLEQIKNDENSTLIFVGYQAQNTRGRKI
LDGEEKVRCRIEKLNSFSAHADQDELIDYIERLKYTPYKVFLVHGEKEQR
EILAKRIISKKIRVELPENYEILIEKKVVLNINTDNMCNFASYRLMPFSG
FIVEKDDRIEINDKNWFDMIWNEEYMALPDMSHDKIIENIEYLFNIKILS
KNRIKEFWEEFCKGQKAAIKYITQVHRKNPNTGRRNWNPPEGDFTDNEIE
KLYETAYNTLLSLIKYDKNKVYNILINFNPKL

3D structure

PDB

8z99 Structural basis for the activity of the type VII CRISPR-Cas system.

Chain

Resolution

3.2 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	H	E32 Q33 H64 L65 D99 F100 I103 Y198 F230 A231 R234 S255 P256 M257 N294 N297 A314 S315 G316 M317 E319 G320 G321 R322 L324 N325 Y343 H373 S527 K528 N529 R530 N556 N558 T559 R561 N563 N565 K608	E32 Q33 H64 L65 D99 F100 I103 Y198 F227 A228 R231 S252 P253 M254 N291 N294 A311 S312 G313 M314 E316 G317 G318 R319 L321 N322 Y340 H370 S500 K501 N502 R503 N529 N531 T532 R534 N536 N538 K581
BS02	ZN	H	H62 H64 H148	H62 H64 H148

External links

PDB	RCSB:8z99, PDBe:8z99, PDBj:8z99
PDBsum	8z99
PubMed	39143216

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