Structure of PDB 8y38 Chain H

Receptor sequence

>8y38H (length=145) Species: 1280 (Staphylococcus aureus)

MRQTFMANESNIERKWYVIDAEGQTLGRLSSEVASILRGKNKVTYTPHVD
TGDYVIVINASKIEFTGNKETDKVYYRHSNHPGGIKSITAGELRRTNPER
LIENSIKGMLPSTRLGEKQGKKLFVYGGAEHPHAAQQPENYELRG

3D structure

• PDB: 8y38 Synthetic macrolides overcoming MLS B K-resistant pathogens.
• Chain: H
• Resolution: 2.58 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	H	M1 R2 Q3 T4 M6 G27 R28 S31 S35 R38 K40 H48 T66 G67 K69 K73 Y75 Y76 R77 H78 S79 N80 H81 P82 G83 K86 R100 E103 S105 G108 M109 T113 R114 L115 K121 H133 Q136 Q137	M1 R2 Q3 T4 M6 G27 R28 S31 S35 R38 K40 H48 T66 G67 K69 K73 Y75 Y76 R77 H78 S79 N80 H81 P82 G83 K86 R100 E103 S105 G108 M109 T113 R114 L115 K121 H133 Q136 Q137

Gene Ontology

Molecular Function

• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0017148 negative regulation of translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8y38, PDBe:8y38, PDBj:8y38
• PDBsum: 8y38
• PubMed: 38992047
• UniProt: Q7A089|RL13_STAAW Large ribosomal subunit protein uL13 (Gene Name=rplM)