Structure of PDB 8w2j Chain H

Receptor sequence

>8w2jH (length=761) Species: 9606 (Homo sapiens) [Search protein sequence]

ASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVE
GGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGI
TNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAG
LVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGR
HCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNII
IIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDR
ILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQK
AMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAP
AAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLG
RGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEA
RGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSAS
GTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEH
MTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGH
LQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVI
GLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAA
YVSGELEHVTR

3D structure

PDB

8w2j Structural basis for allosteric regulation of human phosphofructokinase-1.

Chain

Resolution

3.1 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FBP	H	R565 R654	R555 R644
BS02	FBP	H	R470 T527 S529 M572 H660 R734	R460 T517 S519 M562 H650 R724
BS03	ATP	H	T193 Q197 S255 R419 R423 A456 G457 R461	T183 Q187 S245 R409 R413 A446 G447 R451
BS04	ATP	H	G24 G25 Y55 R88 C89 G118 G120	G14 G15 Y45 R78 C79 G108 G110
BS05	ATP	H	W227 L228 R246 W382 K386 K392	W217 L218 R236 W372 K376 K382

External links

PDB	RCSB:8w2j, PDBe:8w2j, PDBj:8w2j
PDBsum	8w2j
PubMed	39183237
UniProt	P17858\|PFKAL_HUMAN ATP-dependent 6-phosphofructokinase, liver type (Gene Name=PFKL)

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