Structure of PDB 8vis Chain H

Receptor sequence
>8visH (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
ILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPR
DWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTK
DIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDV
CNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGI
VSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGIE
3D structure
PDB8vis Human TMPRSS11D complexed with a disulfide-linked autoinhibitory DDDDK peptide
ChainH
Resolution1.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H H227 H269 Y316 A363 C364 Q365 G366 S368 V387 S388 W389 G390 H41 H83 Y130 A177 C178 Q179 G180 S182 V201 S202 W203 G204
BS02 peptide H S197 N219 F284 T285 K286 H289 S290 V291 C292 E375 R379 L380 W381 S11 N33 F98 T99 K100 H103 S104 V105 C106 E189 R193 L194 W195
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8vis, PDBe:8vis, PDBj:8vis
PDBsum8vis
PubMed
UniProtO60235|TM11D_HUMAN Transmembrane protease serine 11D (Gene Name=TMPRSS11D)

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