Structure of PDB 8u7v Chain H

Receptor sequence

>8u7vH (length=471) Species: 9606 (Homo sapiens) [Search protein sequence]

YVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKITL
KTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFE
QGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSR
DIDFDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDC
DELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQ
AGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLID
AGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADG
GIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFRGMGSLKIAQGVS
GSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLDVLRSMMYSGELKFEKRT
MSAQIEGGVHGLHSYTFLPFT

3D structure

PDB

8u7v Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly.

Chain

Resolution

3.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GTP	H	G113 N230 K238 K242	G102 N215 K223 K227
BS02	NAD	H	T252 R253 D274 S276 Y282 M325 T333 Q441	T237 R238 D259 S261 Y267 M310 T318 Q397
BS03	IMP	H	M70 S329 C331 D364 G365 G387 S388 G413 M414 G415 Q441	M59 S314 C316 D349 G350 G372 S373 G389 M390 G391 Q397
BS04	ATP	H	T159 R161 D162 L185 V186 K206 G207 K208	T148 R150 D151 L170 V171 K191 G192 K193
BS05	GTP	H	K109 I115 F139 S140 T225	K98 I104 F128 S129 T210

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0006183	GTP biosynthetic process

	Cellular Component
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0034774	secretory granule lumen
GO:0035578	azurophil granule lumen
GO:1904813	ficolin-1-rich granule lumen

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8u7v, PDBe:8u7v, PDBj:8u7v
PDBsum	8u7v
PubMed	38323936
UniProt	P20839\|IMDH1_HUMAN Inosine-5'-monophosphate dehydrogenase 1 (Gene Name=IMPDH1)

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