Structure of PDB 8u7q Chain H

Receptor sequence

>8u7qH (length=484) Species: 9606 (Homo sapiens) [Search protein sequence]

YVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKITL
KTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFE
QGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSR
DIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPI
VNDCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLD
LLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAK
NLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPI
IADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKY
RGMGSLKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLDVLRS
MMYSGELKFEKRTMSAQIEGGVHGLHSYTFLPFT

3D structure

PDB

8u7q Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly.

Chain

Resolution

3.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GTP	H	E111 G113 N198 N230 K238 K242	E100 G102 N187 N219 K227 K231
BS02	NAD	H	T252 R253 D274 S275 S276 Y282 N303 C331 T333	T241 R242 D263 S264 S265 Y271 N292 C320 T322
BS03	IMP	H	M70 S329 I330 C331 D364 G365 G366 G387 S388 Y411 G413 M414 G415 S416 Q441 G442	M59 S318 I319 C320 D353 G354 G355 G376 S377 Y400 G402 M403 G404 S405 Q410 G411
BS04	ATP	H	T159 S160 R161 D162 T180 V186 K206 K208	T148 S149 R150 D151 T169 V175 K195 K197
BS05	GTP	H	K109 Q112 I115 H137 G138 F139 S140 T225 D226	K98 Q101 I104 H126 G127 F128 S129 T214 D215

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0006183	GTP biosynthetic process

	Cellular Component
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0034774	secretory granule lumen
GO:0035578	azurophil granule lumen
GO:1904813	ficolin-1-rich granule lumen

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8u7q, PDBe:8u7q, PDBj:8u7q
PDBsum	8u7q
PubMed	38323936
UniProt	P20839\|IMDH1_HUMAN Inosine-5'-monophosphate dehydrogenase 1 (Gene Name=IMPDH1)

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