Structure of PDB 8u7m Chain H

Receptor sequence

>8u7mH (length=451) Species: 9606 (Homo sapiens) [Search protein sequence]

GLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLI
SSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFIT
DPVVLSPSHTVGDVLEAKMRHGFSGIPITGTMGSKLVGIVTSRDIDFLAE
KDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDEA
IIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDV
IVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDG
LRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTV
GHVVKALALGASTVMMGSLLAATTEAPGEVKIAQGVSGSIQDKGSIQKFV
PYLIAGIQHGCQDIGARSLDVLRSMMYSGELKFEKRTMSAQIEGGVTFLP
F

3D structure

PDB

8u7m Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly.

Chain

Resolution

3.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	NAD	H	I45 Q469	I29 Q412
BS02	GTP	H	Q112 I115 F139 S140 G141 K208 T225 D226	Q96 I99 F123 S124 G125 K190 T205 D206
BS03	GTP	H	L194 K195 N198 N230 K238 K242	L176 K177 N180 N210 K218 K222
BS04	ATP	H	T159 R161 D162 L185 V186 K206 K208	T141 R143 D144 L167 V168 K188 K190
BS05	IMP	H	S68 M70 R322 S329 C331 D364 G365 M386 G387 S388 Q441 G442	S52 M54 R302 S309 C311 D344 G345 M366 G367 S368 Q384 G385
BS06	NAD	H	T252 R253 D274 S275 S276 Y282 N303 G324 C331 T333	T232 R233 D254 S255 S256 Y262 N283 G304 C311 T313

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0006183	GTP biosynthetic process

	Cellular Component
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0034774	secretory granule lumen
GO:0035578	azurophil granule lumen
GO:1904813	ficolin-1-rich granule lumen

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8u7m, PDBe:8u7m, PDBj:8u7m
PDBsum	8u7m
PubMed	38323936
UniProt	P20839\|IMDH1_HUMAN Inosine-5'-monophosphate dehydrogenase 1 (Gene Name=IMPDH1)

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