Structure of PDB 8tfp Chain H

Receptor sequence

>8tfpH (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]

VQLQESGPGLVKPSGTLSLTCTVSGGFISSRNWWSWVRQPPGKGLEWIGE
VYHTGITNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCAREVV
GPTTGYFDLWGRGTLVTIVSRRLPPSVFPLAPSSKSTSGGTAALGCLVKD
YFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTY
ICNVNHKPSNTKVDKKVEPK

3D structure

PDB

8tfp An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity That Reverses Carfentanil-Induced Respiratory Depression.

Chain

Resolution

1.78 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	84K	H	W34 E50 N58 E95 G100B	W33 E50 N58 E98 G105

External links

PDB	RCSB:8tfp, PDBe:8tfp, PDBj:8tfp
PDBsum	8tfp
PubMed	37534714

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