Structure of PDB 8r3s Chain H

Receptor sequence
>8r3sH (length=662) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
MFNEKDQLAVDTLRALSIDTIEKANSGHPGLPMGAAPMAYTLWTRHLNFN
PQSKDYFNRDRFVLSAGHGSALLYSLLHVSGSLELEELKQFRQWGSKTPG
HPEYRHTDGVEVTTGPLGQGFAMSVGLALAEDHLAGKFNKEGYNVVDHYT
YVLASDGDLMEGISHEAASFAGHNKLSKLVVLYDSNDISLDGELNKAFSE
NTKARFEAYGWNYLLVKDGNDLEEIDKAITTAKSQEGPTIIEVKTTIGFG
SPNKAGTNGVHGAPLGEVERKLTFENYGLDPEKRFNVSEEVYEIFQNTML
KRANEDESQWNSLLEKYAETYPELAEEFKLAISGKLPKNYKDELPRFELG
HNGASRADSGTVIQAISKTVPSFFGGSADLAGSNKSNVNDATDYSSETPE
GKNVWFGVREFAMGAAVNGMAAHGGLHPYGATFFVFSDYLKPALRLSSIM
GLNATFIFTHDSIAVGEDGPTHEPIEQLAGLRAIPNMNVIRPADGNETRV
AWEVALESESTPTSLVLTRQNLPVLDVPEDVVEEGVRKGAYTVYGSEETP
EFLLLASGSEVSLAVEAAKDLEKQGKSVRVVSMPNWNAFEQQSEEYKESV
IPSSVTKRVAIEMASPLGWHKYVGTAGKVIAIDGFGASAPGDLVVEKYGF
TKENILNQVMSL
3D structure
PDB8r3s Are Transketolases relevant Targets fighting Human Pathogens? A comparative Biochemical, Bioinformatic and Structural Study
ChainH
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.1: transketolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP H F436 Y439 H472 F436 Y439 H472
BS02 TPP H L31 H68 G115 L117 D156 N186 I188 S189 H261 L31 H68 G115 L117 D156 N186 I188 S189 H261
BS03 MG H D156 N186 I188 D156 N186 I188
Gene Ontology
Molecular Function
GO:0004802 transketolase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006098 pentose-phosphate shunt
GO:0006310 DNA recombination
GO:0019253 reductive pentose-phosphate cycle
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8r3s, PDBe:8r3s, PDBj:8r3s
PDBsum8r3s
PubMed
UniProtP99161|TKT_STAAN Transketolase (Gene Name=tkt)

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