Structure of PDB 8p4q Chain H

Receptor sequence

>8p4qH (length=390) Species: 1148 (Synechocystis sp. PCC 6803) [Search protein sequence]

GSHMNITIGRGKTARRAYGIDEIALVPGVRTLDPALADTRWKVGAIEREI
PIIASAMDGVVDSRMAVLLSELGALGVVNLEGIQTRYEDPNPILDRIASV
GKTEFVGLMQELYAEPIKPELITKRIQEIQAAGGIAAVSLTPVGASKYAS
TVAEAGADLLFIQATVVSTAHLSPESVESLDLVKLCQEMPMPVVLGNCVT
YEVSLELMRAGAAAVLVGIGPGAACTSRGVLGVGVPQPTAIADCAAARDD
YLQETGRYVPVIADGGIITGGDICKCIACGADAVMIGSPIARAAEAPGRG
FHWGMATPSPVLPRGTRINVGTTGTIREILVGPAKLDDGTHNLLGAIKTS
MGTLGAKDMKEMQQVDVVIAPSLLTEGKVYQKAQQLGMGK

3D structure

PDB

8p4q GuaB3, an overlooked enzyme in cyanobacteria's toolbox that sheds light on IMP dehydrogenase evolution.

Chain

Resolution

1.88 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	IMP	H	S52 M54 G219 A220 C222 D261 G263 I283 G284 S285 H299 G301 M302 A303 R311	S55 M57 G222 A223 C225 D264 G266 I286 G287 S288 H302 G304 M305 A306 R314
BS02	XMP	H	S52 M54 G219 A220 C222 S224 D261 G263 G284 H299 G301 M302 A303	S55 M57 G222 A223 C225 S227 D264 G266 G287 H302 G304 M305 A306

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0016491	oxidoreductase activity

	Biological Process
GO:0006164	purine nucleotide biosynthetic process

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8p4q, PDBe:8p4q, PDBj:8p4q
PDBsum	8p4q
PubMed	37875114
UniProt	P73853

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