Structure of PDB 8oha Chain H

Receptor sequence
>8ohaH (length=334) Species: 267671 (Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130) [Search protein sequence]
AMTRIAINGFGRIGRLVFRAGIKDPNLEFVAINDLVTPDNLAYLLKYDST
HGRFQGTVEHTEKELIVDGKKILCVSERDPEKLPWKDLKVDYVIESTGLF
TDRVGAEKHIKAGAKKVVISAPAKDKDIPTFVMGVNNEKYNPSNDHIVSN
ASCTTNCLAPIVKVVLDNWGIEEGLMTTIHATTATQPTVDGPSKKDFRGG
RGAMQNIIPASTGAAKAVGLCIPEVNGKLTGMSFRVPTPDVSVVDLTVRT
TKETSLKEISAKMKAASEGAMKGILGYTEDMVVSNDFVSSTLSSIFDMDA
CIELNSRFFKLVSWYDNEMGYSNRVLDLIRYMAK
3D structure
PDB8oha The structure of Leptospira interrogans GAPDH sheds light into an immunoevasion factor that can target the anaphylatoxin C5a of innate immunity.
ChainH
Resolution2.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.1.-
1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD H G8 G10 R11 I12 D33 L34 S95 T96 G97 S119 A152 A183 N316 Y320 G9 G11 R12 I13 D34 L35 S96 T97 G98 S120 A153 A184 N317 Y321
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0006006 glucose metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8oha, PDBe:8oha, PDBj:8oha
PDBsum8oha
PubMed37409124
UniProtQ72QM3

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