Structure of PDB 8jpg Chain H

Receptor sequence

>8jpgH (length=98) Species: 9606 (Homo sapiens)

LDKNTVHDQEHIMEHLEGVINKPEAEMSPQELQLHYFKMHDYDGNNLLDG
LELSTAITHVHQAPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKS

3D structure

• PDB: 8jpg Structure of full-length ERGIC-53 in complex with MCFD2 for cargo transport.
• Chain: H
• Resolution: 6.76 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	H	D129 N131 D133 Y135 E140	D83 N85 D87 Y89 E94
BS02	CA	H	D81 D83 N85 L87 L88 E92	D41 D43 N45 L47 L48 E52
BS03	ZN	H	H51 H55 H99 H101	H11 H15 H59 H61

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0005515 protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0015031 protein transport
• GO:0016192 vesicle-mediated transport

Cellular Component

• GO:0005783 endoplasmic reticulum
• GO:0005789 endoplasmic reticulum membrane
• GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
• GO:0005794 Golgi apparatus
• GO:0012507 ER to Golgi transport vesicle membrane
• GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane

External links

• PDB: RCSB:8jpg, PDBe:8jpg, PDBj:8jpg
• PDBsum: 8jpg
• PubMed: 38493152
• UniProt: Q8NI22|MCFD2_HUMAN Multiple coagulation factor deficiency protein 2 (Gene Name=MCFD2)