Structure of PDB 8ir3 Chain H

Receptor sequence

>8ir3H (length=122) Species: 9606 (Homo sapiens) [Search protein sequence]

AKIKARDLRGKKKEELLKQLDDLKVELSQLRVAKVTGGAASKLSKIRVVR
KSIARVLTVINQTQKENLRKFYKGKKYKPLDLRPKKTRAMRRRLNKHEEN
LKTKKQQRKERLYPLRKYAVKA

3D structure

PDB

8ir3 Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.

Chain

Resolution

3.5 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	H	K3 K5 R7 A41 S45 R48 K52 A55 R56 L58 T59 N62 Q63 K66 L81 R84 K86 T88 R89 R92	K2 K4 R6 A40 S44 R47 K51 A54 R55 L57 T58 N61 Q62 K65 L80 R83 K85 T87 R88 R91
BS02	rna	H	R70 K77 R93 L95 N96 K97 H98 N101 K106 R109 K110 R112 L113	R69 K76 R92 L94 N95 K96 H97 N100 K105 R108 K109 R111 L112

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8ir3, PDBe:8ir3, PDBj:8ir3
PDBsum	8ir3
PubMed	37491604
UniProt	P42766\|RL35_HUMAN Large ribosomal subunit protein uL29 (Gene Name=RPL35)