Structure of PDB 8iau Chain H

Receptor sequence
>8iauH (length=412) Species: 171101 (Streptococcus pneumoniae R6) [Search protein sequence]
MNKRVKIVATLGPAVEIRGGKKFGEDGYWGEKLDVEASAKNIAKLIEAGA
NTFRFNFSHGDHQEQGERMATVKLAEKIAGKKVGFLLDTKGPEIRGVNIP
NTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVNEVRAICEETG
NGHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQK
MIIKKVNAAGKVVITATNMLETMTEKPRATRSEVSDVFNAVIDGTDATML
SGESANGKYPLESVTTMATIDKNAQALLNEYGRLDSDSFERNSKTEVMAS
AVKDATSSMDIKLVVTLTKTGHTARLISKYRPNADILALTFDELTERGLM
LNWGVIPMLTDAPSSTDDMFEIAERKAVEAGLVESGDDIVIVAGVPVGEA
VRTNTMRIRTVR
3D structure
PDB8iau Functional and structural characterization of Streptococcus pneumoniae pyruvate kinase involved in fosfomycin resistance.
ChainH
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FBP H S382 T384 T407 K408 T409 H411 T412 V490 R491 S293 T295 T318 K319 T320 H322 T323 V401 R402
BS02 MG H E250 D274 E161 D185
BS03 OXL H K248 A271 G273 D274 T306 K159 A182 G184 D185 T217
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iau, PDBe:8iau, PDBj:8iau
PDBsum8iau
PubMed37286036
UniProtQ8DQ84

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