Structure of PDB 8h66 Chain H

Receptor sequence
>8h66H (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]
GIIEFHVIGNSNRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTL
ALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEY
HIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLM
ECELNPRIPYT
3D structure
PDB8h66 Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications.
ChainH
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1VU H L531 I576 V577 F578 C579 V581 Q586 V587 G589 G591 T592 T612 Y613 A618 Y621 F622 K624 L30 I75 V76 F77 C78 V80 Q85 V86 G88 G90 T91 T111 Y112 A117 Y120 F121 K123
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

View graph for
Molecular Function
External links
PDB RCSB:8h66, PDBe:8h66, PDBj:8h66
PDBsum8h66
PubMed37040526
UniProtQ92830|KAT2A_HUMAN Histone acetyltransferase KAT2A (Gene Name=KAT2A)

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