BioLiP

PDB

8gsq Structure-based discovery of an antipsychotic drug, paliperidone, as a modulator of human superoxide dismutase 1: a potential therapeutic target in amyotrophic lateral sclerosis.

Chain

Resolution

2.1 Å

3D
structure

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Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

Molecular Function

GO:0004784

superoxide dismutase activity

copper ion binding

protein binding

zinc ion binding

antioxidant activity

oxidoreductase activity

GO:0030346

protein phosphatase 2B binding

GO:0031267

small GTPase binding

GO:0042802

identical protein binding

GO:0042803

protein homodimerization activity

GO:0046872

metal ion binding

GO:0051087

protein-folding chaperone binding

	Biological Process
GO:0000302	response to reactive oxygen species
GO:0000303	response to superoxide
GO:0001541	ovarian follicle development
GO:0001819	positive regulation of cytokine production
GO:0001890	placenta development
GO:0001895	retina homeostasis
GO:0002262	myeloid cell homeostasis
GO:0006749	glutathione metabolic process
GO:0006801	superoxide metabolic process
GO:0006879	intracellular iron ion homeostasis
GO:0006915	apoptotic process
GO:0006979	response to oxidative stress
GO:0007283	spermatogenesis
GO:0007566	embryo implantation
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0008089	anterograde axonal transport
GO:0008090	retrograde axonal transport
GO:0008217	regulation of blood pressure
GO:0008340	determination of adult lifespan
GO:0009408	response to heat
GO:0009410	response to xenobiotic stimulus
GO:0010467	gene expression
GO:0019226	transmission of nerve impulse
GO:0019228	neuronal action potential
GO:0019430	removal of superoxide radicals
GO:0032287	peripheral nervous system myelin maintenance
GO:0032930	positive regulation of superoxide anion generation
GO:0033081	regulation of T cell differentiation in thymus
GO:0035234	ectopic germ cell programmed cell death
GO:0040014	regulation of multicellular organism growth
GO:0042542	response to hydrogen peroxide
GO:0042554	superoxide anion generation
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043087	regulation of GTPase activity
GO:0043410	positive regulation of MAPK cascade
GO:0043524	negative regulation of neuron apoptotic process
GO:0045471	response to ethanol
GO:0046620	regulation of organ growth
GO:0046716	muscle cell cellular homeostasis
GO:0048538	thymus development
GO:0048678	response to axon injury
GO:0050665	hydrogen peroxide biosynthetic process
GO:0050728	negative regulation of inflammatory response
GO:0050766	positive regulation of phagocytosis
GO:0051093	negative regulation of developmental process
GO:0051881	regulation of mitochondrial membrane potential
GO:0060047	heart contraction
GO:0060052	neurofilament cytoskeleton organization
GO:0060087	relaxation of vascular associated smooth muscle
GO:0060088	auditory receptor cell stereocilium organization
GO:0072593	reactive oxygen species metabolic process
GO:0099610	action potential initiation
GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000242	negative regulation of reproductive process

Biological Process

GO:0000302

response to reactive oxygen species

GO:0000303

response to superoxide

GO:0001541

ovarian follicle development

GO:0001819

positive regulation of cytokine production

GO:0001890

placenta development

GO:0001895

retina homeostasis

GO:0002262

myeloid cell homeostasis

GO:0006749

glutathione metabolic process

GO:0006801

superoxide metabolic process

GO:0006879

intracellular iron ion homeostasis

GO:0006915

apoptotic process

GO:0006979

response to oxidative stress

GO:0007283

spermatogenesis

GO:0007566

embryo implantation

GO:0007605

sensory perception of sound

GO:0007626

locomotory behavior

GO:0008089

anterograde axonal transport

GO:0008090

retrograde axonal transport

GO:0008217

regulation of blood pressure

GO:0008340

determination of adult lifespan

GO:0009408

response to heat

GO:0009410

response to xenobiotic stimulus

GO:0010467

gene expression

GO:0019226

transmission of nerve impulse

GO:0019228

neuronal action potential

GO:0019430

removal of superoxide radicals

GO:0032287

peripheral nervous system myelin maintenance

GO:0032930

positive regulation of superoxide anion generation

GO:0033081

regulation of T cell differentiation in thymus

GO:0035234

ectopic germ cell programmed cell death

GO:0040014

regulation of multicellular organism growth

GO:0042542

response to hydrogen peroxide

GO:0042554

superoxide anion generation

GO:0043065

positive regulation of apoptotic process

GO:0043066

negative regulation of apoptotic process

GO:0043087

regulation of GTPase activity

GO:0043410

positive regulation of MAPK cascade

GO:0043524

negative regulation of neuron apoptotic process

GO:0045471

response to ethanol

GO:0046620

regulation of organ growth

GO:0046716

muscle cell cellular homeostasis

GO:0048538

thymus development

GO:0048678

response to axon injury

GO:0050665

hydrogen peroxide biosynthetic process

GO:0050728

negative regulation of inflammatory response

GO:0050766

positive regulation of phagocytosis

GO:0051093

negative regulation of developmental process

GO:0051881

regulation of mitochondrial membrane potential

GO:0060047

heart contraction

GO:0060052

neurofilament cytoskeleton organization

GO:0060087

relaxation of vascular associated smooth muscle

GO:0060088

auditory receptor cell stereocilium organization

GO:0072593

reactive oxygen species metabolic process

GO:0099610

action potential initiation

GO:1902177

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

GO:2000242

negative regulation of reproductive process

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005759	mitochondrial matrix
GO:0005777	peroxisome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0032839	dendrite cytoplasm
GO:0032991	protein-containing complex
GO:0043025	neuronal cell body
GO:0070062	extracellular exosome
GO:1904115	axon cytoplasm

Cellular Component

extracellular region

extracellular space

nucleus

nucleoplasm

cytoplasm